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The classic backpack style, durable and fashionable design is suitable for any attire for any occasion, such as work, business, dating, daily, travel, school, and it will be very comfortable to carry. Capacity: Through the clever space design, the spacious space is enough to easily store your belongings and necessities, such as: A4 items, ipad, mobile phones, cosmetics, folding umbrellas, keys, etc. Perfect choice: This handbag is the perfect choice for your lover, friends or family. In addition, its simple and elegant appearance is suitable for many occasions, such as work, travel, shopping, etc. Easy to wash: All women's handbags have been pre-washed to minimize shrinkage. Machine wash | Open dry, do not dry by machine. These bags are sewn by hand and may vary in size by 0.5" to 1". Due to differences in lighting and screen settings, small color changes may occur."br"After-sales service: If you have any questions, please feel free to contact us.
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Gut is a leading international journal in gastroenterology and hepatology and has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage in all areas of gastroenterology and hepatology. Regular features include articles by leading authorities describing novel mechanisms of disease and new management strategies, both diagnostic and therapeutic, likely to impact on clinical practice within the foreseeable future.
Our new online collection highlights all research relating to the COVID-19 pandemic published by Gut, Frontline Gastroenterology and BMJ Open Gastroenterology. It is updated regularly as new articles are published.
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Spatial profiling of gastric cancer metastases reveals principles of tumour dissemination
To cite: Sundar R, Liu DH, Hutchins GG, et al. Gut 2021;70:1823-1832.
Read the full article here: link
Objective: Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis.
Conclusions: In GC, regional lymph node metastases are likely to originate from deeper subregions of the primary tumour. Future clinical trials of novel targeted therapies must consider assessment of deeper subregions of the primary tumour and/or metastases as several therapeutically relevant genes are only mutated, overexpressed or amplified in these regions.